Symbol
Name
ID

Pklr
pyruvate kinase liver and red blood cell
MGI:97604

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes

Polyclonal elevation of IgM

Increased circulating antibody level

Abnormality of blood and blood-forming tissues

Abnormal bleeding

Gingival bleeding

Pancytopenia

Abnormal erythrocyte morphology

Reduced red cell pyruvate kinase level

Decreased hemoglobin concentration

Erythroid hyperplasia

Reticulocytosis

Anemia

Chronic hemolytic anemia

Congenital hemolytic anemia

Fava bean-induced hemolytic anemia

Nonspherocytic hemolytic anemia

Spontaneous hemolytic crises

Anisocytosis

Heinz bodies

Poikilocytosis

Increased red cell osmotic fragility

Leukocytosis

Leukopenia

Impaired neutrophil bactericidal activity

Abnormality of coagulation

Thrombocytopenia

Splenic infarction

Splenic rupture

Splenomegaly

Disease(s) Associated with PKLR

congenital nonspherocytic hemolytic anemia

Gaucher's disease

malaria

pyruvate kinase deficiency of red cells

Mouse Phenotypes

enlarged spleen

abnormal common myeloid progenitor cell morphology

abnormal erythropoiesis

anemia

hemolytic anemia

increased erythroid progenitor cell number

increased erythroblast number

abnormal erythrocyte morphology

decreased erythrocyte cell number

decreased hematocrit

decreased hemoglobin content

increased mean corpuscular volume

increased nucleated erythrocyte cell number

reticulocytosis

increased erythrocyte clearance

increased erythrocyte osmotic fragility

Availability

Mouse Genotype

Pklr^char4/Pklr^char4

Pklr^slc/Pklr^slc

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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